Circu Plus_60 V.GELS-LEPIVITS
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CIRCU PLUS - LEPIVITS

 fights venous insufficiency

Specific compound based on natural plant extracts that helps your body to recover light legs*. Circu Plus ensures the proper functioning of blood vessels**.

This specific complex contains:

- *Butcher’s broom and European horse chestnut support venous circulation and contribute to a sensation of light legs;

- **Vitamin C ensures the normal functioning of blood vessels;

- Zinc and selenium ensure the proper functioning of the immune system;

- Vitamins C and E and selenium help protect cells against oxidative stress.

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35,00 €

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Heavy legs and varicose veins can be the symptoms of poor venous circulation

Chronic venous insufficiency can lead to circulatory problems causing several symptoms, such as a sensation of heavy legs, tingling, muscle cramps as well as varicose veins that can degenerate into edema and cause dermatological damage.

Act against the symptoms of venous insufficiency

Do not hesitate to consult your doctor in case of recurrent symptoms. Simple daily gestures can help relieve your symptoms (sprinkle cold water on your legs and massage regularly, wear compression stockings). Practicing sports helps prevent this condition.

The butcher’s broom is rich in saponins

Fragon or the butcher’s broom contains vasoconstrictor properties from saponins[1] and a venotonic action from aescin contained in horse chestnut[2]. Recent studies have highlighted the interest of aescin[3] as an anti-inflammatory and anti-ede as active principle increasing venous tone. Aescin is involved in the inflammatory cascade. Antagonist of the decrease of A.T.P, this molecule inhibits phospholipase A2, elastase and the attachment of neutrophils to the endothelium[4].

Oligomeric proanthocyanidins (OPC)

Oligomeric proanthocyanidins (OPCs) contained in grape seeds act effectively on the symptoms of venous insufficiency, notably by improving capillary fragility [5], collagen stabilization, elastin protection and have a recognized antioxidant action [6]. A double-blind, placebo-controlled study on 60 patients with chronic venous insufficiency showed a significant improvement in symptoms after 30 days of treatment with a bilberry extract titrated to 25% anthocyanins [7].

Blueberry extract rich in anthocyanins

A double-blind, placebo-controlled study of 60 patients with chronic venous insufficiency showed a significant improvement in symptoms after 30 days of treatment with a bilberry extract with a 25% anthocyanin content [7].

Bromelain

Bromelain helps reduce platelet aggregation[8] . It acts on inflammation, edema and pain, both by direct fibrinolysis of clots, by activation of anti-inflammatory prostaglandins and by inhibition of bradykinin. Quercetin modifies eicosanoid biosynthesis, prevents platelet aggregation and promotes relaxation of cardiovascular smooth muscle[9] . Selenium helps to reduce the damage to the venous walls. Zinc and vitamins C & E limit leukocyte degranulation responsible for tissue extravasation [10].

Circu Plus nutritional information 

Active ingredients 

2 pills

AJR%*

Butcher’s broom including  saponins

200mg - 20mg

-

Extract of grape seeds

including OPC**

100mg

95mg

-

Blueberry extract including anthocyans

100mg - 25mg 

-

Horse chestnut extract

100mg

-

of which aescines

20mg

-

Bromelain2500/g

200mg

 -

Quercetin

190mg

-

Vitamin C  180mg 225
Vitamin E   30mg  250
Selenium 104μg 189
Zinc  20mg  200

* Recommended daily intake (directive 2008/100/CE modifiant -> arrêté 08.01.1992)
**Proanthocyanidin oligomers.

[1]Almeida Cyrino FZG1, Balthazar DS1, Sicuro FL1, Bouskela E1. Effects of venotonic drugs on microcirculation :comparisonbetween Ruscus extract and micronized diosmin; Clin Hemorheol Microcirc. 2018;68(4):371-382. doi: 10.3233/CH-170281. [2] Traitment of chronic veinous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Suter A et al. Advances in therapy, 23(1):179-190. 2006. [3] Aescin : pharmacology, pharmacokinetics and therapeutic profile. Sirtori CR. Pharmacological research. 44(3):183-193. 2001. [4] DUDEK-MAKUCH M., STUSZINSKA-SROKA E. Horse chestnut – efficacy and safety in chronic venous insufficiency : an overview. Revista Brasileira Revista de Farmacognosia 2015, 26 (1) : 9 p. [5] Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005 Jan;81(1 Suppl):243S-255S. Review. Integral text : www.ajcn.org. [6]Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Fine AM1. Altern Med Rev. 2000 Apr;5(2):144-51. [7] Gatta L., « Experimental single-blind study: 60 pts with venous insufficiency received bilberry extract equivalent to 173 mg antho cyanins daily of placebo for 30 days », Fitoterapia, 1988, 115:109-116. K [8] elly GS « Bromelain : A Literature Review and Discussion of its Therapeutic Applications; [9]The role of quercetin, flavonols and flavones in modula
Conditionnement
60 pills
Composition
Butcher’s broom extract (Ruscus aculeatus ricehome extract), extract of Sophora japonica (flower bud) including Rutin, Vitamin C (L-ascorbic), Horse chestnut (Aesculus hippocastanum seed extract), grape seed extract / Vitis vinifera (including OPC), Vitamin B1 (thiamine hydrochloride); bulking agent: rice starch, capsule shell: 100% vegetable pullulan.
Main indication
Insuffisance veineuse
Specific indication
Insuffisance veineuse
Dosage
2 capsules a day, with a glass of water, with the meal.
Recommandations
It is recommended to not consume over the recommended daily dose. A nutritional supplement does not doesn’t replace a balanced and a healthy diet. Nutritional supplements are not medication. Keep from children. Inform your doctor and/or pharmacist if you are simultaneously taking other drugs. Ask your therapists if you’re pregnant or nurturing. Keep from light and humidity.
Notification number
NUT 3760/62
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